7:30-8:30     | Educational breakfast workshop

• Zdenko Kovac (Zagreb, Croatia)
  CASE-BASED METHODOLOGY IN SYNTHETIC LEARNING/TEACHING OF PATHOPHYSIOLOGY
• Leonid P. Churilov (St. Petersburg , Russia)
  SCIENCE OF BODY IMPERFECTION: FROM PATHOPHYSIOLOGY TO PATHOBIOLOGY VIA INNOVATIVE INTERDISCIPLINARY TEACHING

8:00-9:30     | Symposium 4

Pathophysiological pathways: Neurodegenerative disease and pain

• Guy Rouleau (Montréal, Canada)
  MOLECULAR PATHOGENESIS OF MOTOR NEURON DISEASES: INSIGHTS FROM GENETICS
• Wail Benjelloun (Rabat, Morroco), Meryem Alamy, Nouria Lakhdar-Ghazal
  EFFECTS OF UNDERNUTRITION ON BRAIN BIOCHEMISTRY, BEHAVIOR AND   CIRCADIAN RHYTHM IN RAT
• Majid Nikpay (Montréal, Canada), Ondřej Šeda, Johanne Tremblay, Milan   Petrovich, Daniel Gaudet, Theodore Kotchen, Allen Cowley Jr, Pavel Hamet
  GENETIC ANALYSIS OF SUBSTANCE USE, OBESITY-RELATED TRAITS, STRESS RESPONSE, HEART RATE AND BLOOD PRESSURE REVEALED SHARED GENES, OVERREPRESENTED IN SYNAPSES
• Yue-Ping Yu (Hangzhou, China), Yi-Lu Ye, Qi Zhang, Hua Ji, Jian-Ting Zhang
  PROTECTIVE EFFECT OF ERYTHROPOIETIN ON CHRONIC CEREBRAL ISCHEMIA ADMINISTRATED INTRANASALLY

8:00-9:30     | Symposium 5

Pathophysiological pathways: Inflammation, infection and immune system diseases
Chair: Tarik Möröy (Montréal, Canada)

• Usha Sachdeva (Manama, BAHRAIN), G Sundaresan, Ramesh Lal Bijlani, D.N. Rao
  HUMAN BODY TEMPERATURE AND IMMUNOGLOBULIN CIRCADIAN RHYTHMS DURING EXPOSURE TO PROLONGED DARKNESS
• Vyacheslav Adarichev (Bronx, USA), Toni Forde, Elena Kudryavtseva
  ARTHRITIS SEVERITY IS UNDER CONTROL OF MURINE CHROMOSOME 15 CARTILAGE REMODELING GENES WHOSE EXPRESSION IS EFFECTED BY SEX
• Michel Tremblay (Montréal, Canada)
  TC-PTP FUNCTION IN IMMUNE CELLS AND ITS INHIBITION FOR POTENTIAL THERAPEUTIC APPLICATIONS IN HUMAN DISEASES.
• Tarik Möröy (Montréal, Canada)
  GROWTH FACTOR INDEPENDENT 1 (Gfi1) IS REQUIRED FOR INITIATION AND MAINTENANCE OF T-CELL LEUKEMIA

8:00-9:30     | Workshop 4

Purinergic signaling in health and disease
• Ryszard Grygorczyk (Montréal, Canada)

• Eduardo R. Lazarowski (Chapel Hill, USA)
  DIFFERENTIAL REGULATION OF ATP RELEASE IN AIRWAY EPITHELIA
• John W. Hanrahan (Montréal, Canada)
  MECHANISM OF MECHANICALLY-INDUCED FLUCTUATIONS IN CYTOSOLIC ATP
• Alexander Mongin (Albany, USA)
  PURINERGIC REGULATION OF MICROGLIAL MOTILITY, ION TRANSPORT, AND NEUROTRANSMITTER RELEASE
• Nickolai Dulin (Chicago, USA)
  DUAL REGULATION OF VASCULAR SMOOTH MUSCLE CELL GROWTH AND PHENOTYPE BY EXTRACELLULAR ATP
• Jean Sévigny (Québec, Canada)
  THE SAME ECTO-ATPASE ON SMOOTH MUSCLE CELLS AND ON ENDOTHELIAL CELLS REGULATES DIFFERENTLY EXTRACELLULAR NUCLEOTIDE-INDUCED VASOMOTION
  
  

9:30-10:00   | Coffee break 10:00-11:00 | Plenary Session 3

Systems Biology (sponsored by the Institute of Genetics CIHR)

• Yuxin Yin (Beijing, China)
  NETWORK OF P53 AND PTEN TUMOR SUPPRESSORS: SYSTEMS BIOLOGY OF THE GENOME
  

11:00-13:00 | Symposium 6

Pathophysiological pathways: Ageing

• Barry Zirkin (Baltimore, USA)
  MECHANISMS AND CONSEQUENCES OF LEYDIG CELL AGING
• Chantal Autexier (Montreal, Canada)
  UNIQUE CHARACTERISTICS OF TELOMERASE AND TELOMERES AS POTENTIAL TARGETS IN AGING AND CANCER
• Paul Ernsberger (Cleveland, USA), Liza Escobedo, Alexandra Moore, Richard Koletsky
  OXIDATIVE STRESS IS ELEVATED IN SHROB RELATIVE TO SHR AND MAY CONTRIBUTE TO COMPLICATIONS OF METABOLIC SYNDROME
• Ondřej Šeda (Montréal, Canada), Lucie Sedova, Carole Long, Mounsif Haloui, Maxime Caron, Johanna Sandoval, Ghislain Rocheleau, Mark Woodward, Michel Marre, Stephen Harrap, John Chalmers, Johanne Tremblay, Pavel Hamet
  GENOME-WIDE ASSOCIATION AND NETWORK ANALYSIS OF TELOMERE LENGTH IN TWO DISTINCT CAUCASIAN COHORTS
• Hano Takuzo (Wakayama, Japan), Kawabe Tetsuya
  EFFECTS OF TAURINE AND ESTROGEN ON ENDOTHERIAL PROGENITOR CELL SENESCENCE IN SPONTANEOUSLY HYPERTENSIVE RATS
• Silvia Liskova (Prague, Czech Republic), Miriam Petrova, Jaroslav Kuneš, Josef Zicha
  EFFECT OF AGING AND ACUTE CYCLOOXYGENASE INHIBITION ON NOREPINEPHRINE-INDUCED CONTRACTION OF FEMORAL ARTERIES OF SPONTANEOUSLY HYPERTENSIVE RATS AND WISTAR RATS

11:00-13:00 | Symposium 7

Novel Diabetic Therapeutic pathways (sponsored BMS/AZ)

• Muaz Belviranlý (Konya, Turkey), Hakký Gökbel, Nilsel Okudan, Sadýk Büyükbaþ
  EFFECTS OF GRAPE SEED EXTRACT SUPPLEMENTATION ON OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE IN LIVER TISSUE OF DIABETIC RATS
• Basma A.M.Ahmed (Montréal, Canada), Catherine Michel, Ondřej Šeda, Julie L.Lavoie
  ROLE OF (PRO) RENIN RECEPTOR IN DEVELOPMENT OF OBESITY, A NOVEL THEORY
• Richard Koletsky (Cleveland, USA), Brian Chen, Diana Hou, Paul Ernsberger
  SHROB ARE HYPERGLUCAGONEMIC AND HYPERINSULINEMIC: TREATMENT WITH SPECIFIC PEPTIDASE (DPP-IV) INHIBITOR LOWERS GLUCAGON, IMPROVING GLUCOSE INTOLERANCE BUT NOT INSULIN RESISTANCE
• Marc Prentki (Montréal, Canada)
  BETA CELL METABOLIC SIGNALING AND DYSFUNCTION IN TYPE 2 DIABETES
• Richard E. Gilbert (Toronto, Canada)
  CONVERGENCE OF PATHWAYS: DPP-IV INHIBITORS AS CARDIOPROTECTIVE AGENTS

11:00-13:00  | Workshop 5

Dietary salt, cardiotonic steroids, hypertension and renal disease
• Alexei Bagrov (Baltimore, USA)
INTERACTION OF CARDIOTONIC STEROIDS AND NATRIURETIC PEPTIDES ON THE SODIUM PUMP:IMPACT ON AGING, FIBROSIS, AND SALT-SENSITIVITY

• Frans H. Leenen (Ottawa, Canada)
  NEUROMODULATION BY ALDOSTERONE - 'OUABAIN' PATHWAY IN SALT SENSITIVE HYPERTENSION
• Jerry B. Lingrel (Cincinnati, USA)
  GENE TARGETED MICE DEMONSTRATE THAT THE CARDIOTONIC STEROID/OUABAIN BINDING SITE OF THE NA,K-ATPASE PLAYS A ROLE IN BLOOD PRESSURE REGULATION
• Zi-Jian Xie (Toledo, USA)
  THE NA/K-ATPASE/SRC COMPLEX AND CARDIOTONIC STEROID-ACTIVATED PROTEIN KINASE CASCADES
• Joseph I. Shapiro (Toledo, USA)
  DO CARDIOTONIC STEROIDS PROVIDE THE MOLECULAR LINK BETWEEN DIETARY SALT AND CARDIOVASCULAR OUTCOMES?
  
  

13:00-14:30  | Lunch — Exhibit

13:00-14:30  | Poster Session C - Nervous, metabolic and immune
                        systems

14:00-16:30   | Workshop 7

Epithelial/Mesenchymal Transition /organ fibrosis and the myofibroblast

• Chaired by Laszlo Rosivall (Budapest, Hungary) and Andras Kapus
  (Toronto, Canada)

• Harold Chapman (San Francisco, USA)
  INTEGRIN DEPENDENT CROSS-TALK BETWEEN -CATENIN AND SMAD SIGNALING REGULATES EMT
• Anna Mae Diehl (Durham, USA)
  HEDGEHOG PATHWAY ACTIVATION PROMOTES EPITHELIAL-TO-MESENCHYMAL TRANSITIONS AND OTHER EVENTS THAT EXPAND MYOFIBROBLAST POPULATIONS IN INJURED LIVERS
• Boris Hinz (Toronto, Canada)
  THE MECHANISMS OF MYOFIBROBLAST CONTRACTION
• Yeesim Khew-Goodall (Adelaide, Australia)
  MICRORNAS REGULATING EPITHELIAL-MESENCHYMAL TRANSITION AND FIBROBLAST ACTIVATION IN FIBROSIS
• William Schnaper (Chicago, USA)
  NON-CANONICAL SIGNALING NETWORKS REGULATE TGF-β/SMAD3 SIGNALING IN RENAL FIBROGENESIS
  
• Andras Kapus (Toronto, Canada)
  ACTIVATION OF A MYOGENIC PROGRAM IN THE EPITHELIUM
• Michael Zeisberg (Boston, USA)
  EPIGENETIC CONTROL OF FIBROBLAST ACTIVATION

14:30-16:30   | Symposium 8

Biomakers and drug targets in diabetes and cardiovascular diseases (sponsored by Eli Lilly)

• Marju Orho-Melander (Malmo, Sweden)
  INTERACTION BETWEEN DIET AND GENETIC RISK FACTORS FOR OBESITY,   TYPE 2 DIABETES AND DYSLIPIDEMIA
• Bruce McManus (Vancouver, Canada)
  MOLECULAR BIOMARKERS IN CARDIOVASCULAR DISEASES
• Constantin Polychronakos (Montreal, Canada)
  COPY-NUMBER AND OTHER LOW-FREQUENCY ALLELES IN THE GENETICS OF TYPE 1 DIABETES.
• Alaa Badawi (Toronto, Canada), Paul Arora, Bibiana Garcia-Balio, Zari Dastani, Brent Richards, Ahmed El-Sohemy, Suneil Malik, Mohamed Karmali BIOMARKERS OF INNATE IMMUNITY-RELATED INFLAMMATION: EARLY DETECTION AND PREVENTION OF TYPE 2 DIABETES MELLITUS
• Itzik Harosh (Evry, France), Sandrine Braud
  IDENTIFICATION OF NEW TARGET FOR OBESITY AND TYPE II DIABETES TREATMENTS BASED ON GENES ASSOCIATED WITH LEAN PHENOTYPE IN HUMAN

14:30-16:30   | Workshop 6

Cell volume regulation

• Vladimír Štrbák (Bratislava, Slovakia) and Sergei Orlov (Toronto, Canada)

• Ryszard Grygorczyk (Montréal, Canada)
  CYTOPLASMIC GEL BEHAVES AS OSMOSENSOR IN MAMMALIAN CELLS
  
• Sergei Orlov (Montréal, Canada)
  TISSUE-SPECIFIC IMPACT OF PURINERGIC RECEPTORS ON CELL VOLUME ADJUSTMENT
• Yasunobu Okada (Okazaki, Japan)
  ROLES OF ANION CHANNELS IN CELL VOLUME REGULATION, CELL DEATH INDUCTION AND CELL-CELL SIGNALING
• Else Kay Hoffmann (Copenhagen, Denmark)
  ROLE OF VOLUME SENSITIVE ION CHANNELS IN CELL CYCLE CONTROL AND IN THE EARLY STAGE OF APOPTOSIS
• Markus Ritter (Salzburg, Austria)
  THE NON-GASTRIC H+/K+-ATPASE ATP12A (ATP1AL1) ACTS AS ANTI-APOPTOTIC ION TRANSPORTER
• Vladimír Štrbák (Bratislava, Slovakia)
  ROLE OF CHOLESTEROL AND SNARE PROTEINS IN CELL SWELLING-INDUCED INSULIN SECRETION

16:30-17:00 | Coffee Break

17:00-18:00 | Opening of SHR Satellite Symposium

  • Chair: Pavel Hamet (Montréal, Canada)

17:00-18:00 | Plenary Session 4

International Okamoto Awards Lectures

• Peter Libby (Boston, USA)
  INFLAMMATION AND VASCULAR DISEASE: THEORY AND PRACTICE
• Theodore Kurtz (San Francisco, USA)
  NUCLEAR AND MITOCHONDRIAL GENE VARIANTS THAT INFLUENCE HYPERTENSION AND THE METABOLIC SYNDROME: LESSONS FROM THE SHR

18:00-18:45 | ISP Business Meeting

19:30            | Joint Gala Evening ISP & SHR

Okamoto Award Ceremony