8:30-9:15     | ISP Opening Ceremony

9:15-10:15   | Plenary Session 1

Pathophysiological pathways in cancer
• Chair: Qide Han (Beijing, China)

• Tak W. Mak (Toronto, Canada)
  PATHOPHYSIOLOGICAL PATHWAYS: METABOLISM AND CANCER

10:15-10:45  | Coffee Break and opening of exhibits 10:45-12:30  | Symposium 1

Pathophysiological pathways in gastrointestinal and lung diseases
• Chairs: Kayode Adeniyi (Ibadan, Nigeria) and
              Vladimir Jakovljevic (Kragujevac, Serbia)

• Miyako Takaki (Kashihara, Japan)
  PATHOPHYSIOLOGICAL PATHWAYS IN GASTROINTESTINAL DISEASE: GASTROINTESTINAL MOTILITY DISORDERS
• Qutayba Hamid (Montréal, Canada)
  ADVANCES IN THE PATHOGENESIS OF SEVERE ASTHMA
• Zaher Radi (Cambridge, USA), Wade Lawrence, Raj Krishnaraj, Jay Wendling, Rita Huff, John Walker, Jon Lawson, Mark Vogel
  GASTRIC PARIETAL CELL DEPLETION AND ATROPHY FOLLOWING ADMINISTRATION OF A SPHINGOSINE-1-PHOSPHATE 1 AGONIST
• Mehtap Kocak (Ankara, Turkey), Ezgi Ermis, Nuray Yazihan, Ethem Akcil, Cumhur Cokmus
  RELATION OF MIDKINE AND HYPOXIA INDUCIBLE FACTOR-1 WITH CADMIUM EXPOSURE IN HUMAN HEPATOCYTE CELL LINE IN NORMOXIC AND HYPOXIC CONDITIONS
• Jun Wang (Beijing, China), Ran Miao, Jie Liu
  ALTERATIONS OF BONE MARROW DERIVED ENDOTHELIAL PROGENITOR CELLS FOLLOWING ACUTE PULMONARY EMBOLISM IN MICE

10:45-12:30  | Workshop 1

Impact of environmental exposures on the reproductive system
• Vassilios Papadopoulos (Montréal, Canada)

• Kevin Gaido (Washington DC, USA)
  IMPACT OF DEVELOPMENTAL EXPOSURE TO PHTHALATES ON THE MALE REPRODUCTIVE SYSTEM
  
• Jacob de Boer (Amsterdam, The Netherlands)
  ENDOCRINE DISRUPTORS: EXAMPLES OF CONTAMINANTS THAT CAN CAUSE EFFECTS ON THE OFFSPRING OF ANIMALS AND HUMANS
• Gail S. Prins (Chicago, USA)
  DEVELOPMENTAL EXPOSURE TO BISPHENOL A: EPIGENETIC BASIS FOR INCREASED PROSTATE CANCER SUSCEPTIBILITY

10:45-12:30  | Workshop 2

Impact of environmental exposure on public health
• Marie-France Raynault (Montréal, Canada)

• Jack Siemiatycki (Montreal Canada)
  A BROAD OVERVIEW OF RECOGNIZED ENVIRONMENTAL AND LIFESTYLE CAUSES OF CANCER
  

• Marie-Claude Rousseau (Montreal, Canada)
  OCCUPATIONAL EXPOSURE TO LEAD AND CANCER RISK

• Marie-Élise Parent (Montreal, Canada)
  TRAFFIC-RELATED AIR POLLUTION AND PROSTATE CANCER IN MONTREAL

• Anita Koushik (Montreal, Canada)
  THE CONSUMPTION OF FRUITS AND VEGETABLES AND CANCER RISK
  

12:30-14:00   | Lunch — Exhibit 12:30-14:00   | Poster Session A -Gastrointestinal and respiratory
                         systems, and environmental factor 14:00-15:00   | Plenary Session 2

Pharmacogenomics in drug discovery
• Chair: Catalina Lopez-Correa (Montréal, Canada)

• Allen D. Roses (Durham, USA)
  THE GENETICS AND PATHOPHYSIOLOGY OF LATE-ONSET ALZHEIMER’S DISEASE
  

15:00-16:45  | Symposium 2

Pathophysiological pathways in Cancer
• Chair: Michel Tremblay (Montréal, Canada) and
            Michel Bouvier (Montréal, Canada)

• Moshe Szyf (Montréal, Canada)
  THE DYNAMIC METHYLOME AND ITS IMPLICATIONS IN CANCER AND CANCER THERAPEUTICS
• Julie St Pierre (Montréal, Canada)
  REGULATION OF CANCER METABOLISM BY THE PGC-1 TRANSCRIPTIONAL COACTIVATORS
• Rui Gradiz (Coimbra, Portugal), José Manuel Pontes, Francisco Portela, Maria Manuel Donato, Marta Urbano, Lina Carvalho, Maximino Correia Leitão
  MOLECULAR ANALYSIS (K-RAS) OF PANCREATIC CYSTS FLUID AND PREDICTION OF MALIGNANCY
• Serge Hardy (Montréal, Canada), Nau Nau Wong, William J. Muller, Morag Park, Michel L. Tremblay
  OVEREXPRESSION OF THE PROTEIN TYROSINE PHOSPHATASE PRL-2 CORRELATES WITH BREAST CANCER PROGRESSION AND PROMOTES TUMOR FORMATION IN VIVO
  

15:00-16:45  | Symposium 3

Novel pathophysiological approaches and Omics tools
• Chair: Laszlo Rosivall (Budapest, Hungary) and
            Anne-Marie Alarco (Montréal, Canada)

• Shahryar Eghtesadi (Tehran, Iran), Roya Sherafat-Kazemzadeh, Fereidoun Azizi, Parvin Mirmiran, Mahmoud Gohari, Mohamad Reza Vafa, Mehdi Hedayati, Sara Jalali Farahani, Firoozeh Hosseini Esfahani
  INVESTIGATING THE 6 –YEAR MODEL FOR CHANGES IN THE COMPONENTS OF METABOLIC SYNDROME AMONG TEHRANIAN ADULTS BASED ON DIETARY PATTERNS AND COMMON GENETIC POLYMORPHISM IN ADIPONECTIN AND RESISTIN GENES
• Li Hong Fu (Shijiazhuang, China), Bin Cong, Shu jin Li, Chun ling Ma
  HYPOMETHYLATION OF PROXIMAL CPG MOTIF OF PROMOTER MAY REGULATE INTERLEUKIN-10 EXPRESSION IN RHEUMATOID ARTHRITIS PERIPHERAL BLOOD MONONUCLEAR CELLS
• Bing Xiao (Izumo, Japan), Toru Nabika
  EFFECT OF A SMALL GENOMIC FRAGMENT ON CHROMOSOME 1 ON SYMPATHETIC RESPONSE TO STRESSORS: EVALUATION IN RECIPROCAL CONGENIC STRAINS BETWEEN SHRSP AND WKY
• Tommy Nilsson (Montréal, Canada)
  LIVER FUNCTION THROUGH CELL BIOLOGY AND PROTEOMICS: WHY DOES THE LIVER STORE FAT?
• Vincent Giguère (Montréal, Canada)
  CONTROL OF METABOLIC GENE NETWORKS BY NUCLEAR RECEPTORS IN RESPONSE TO PHYSIOLOGICAL CUES, DISEASES AND THE ENVIRONMENT
  

15:00-16:45 | Workshop 3

Pathophysiological Mechanism Relating to Unspecific Back Pain – an Update
• Osmo Hänninen (Kuopio, Finland)
  KINETIC CHAIN OF THE BACK IN PATHOPHYSIOLOGY,POSTURE AND PAIN

• O. Airaksinen (Kuopio, Finland)
  PATHOPHYSIOLOGY OF LUMBAR SPINAL STENOSIS
• H. Wagner (Münster, Germany)
  THE INFLUENCE OF LUMBAR LORDOSIS ON SPINAL STABILITY
• H. C. Scholle (Jena, Germany)
  CHARACTERIZATION OF MUSCULAR MECHANISMS RELATING TO NONSPECIFIC BACK PAIN
• N. Schilling (Jena, Germany)
  EVOLUTIONARY PERSPECTIVES ON THE HUMAN BACK MUSCULATURE – FIBER-TYPE COMPOSITION AND FASCICLE ARCHITECTURE
• C. Anders (Jena, Germany)
  LOW BACK PAIN PATIENTS SUFFER FROM BOTH, CO-ORDINATION DEFICITS AND INADEQUATE FORCE CAPABILITIES OF THEIR TRUNK MUSCLES
  
• J. Reichenbach (Jena, Germany)
  INSIGHTS INTO BIOCHEMICAL MECHANISMS OF PAIN BY USING MR SPECTROSCOPY
  
  

16:45-17:15 | Coffee break16:45-18:00  | Poster Session B - Cancer, ageing, cellular and
                        systems biology

18:00             | Welcome Reception in Exhibit Area